S
- Samurai Jack
- Samurai Jack - Game Boy Color
- Samurai Jack: Samurai Showdown - Mobile phone
- Samurai Jack: The Shadow of Aku - PS2
- Scooby-Doo
- Scooby Doo! Classic Creep Capers - Game Boy Color, N64
- Scooby-Doo Mystery - SNES, & Mega Drive/Genesis
- Scooby-Doo: Mystery of the Fun Park Phantom - PC
- Scooby-Doo! Night of 100 Frights - PS2, Xbox, & GameCube
- Scooby Doo: Mystery Mayhem - PS2, Xbox, GameCube, & Game Boy Advance
- Scooby-Doo and the Cyber Chase - PlayStation
- Scooby-Doo! Unmasked - PS2, Xbox, GameCube, Game Boy Advance, & Nintendo DS
- Scooby-Doo! Who's Watching Who? - Nintendo DS, PSP
- Skeleton Warriors
- Skeleton Warriors - Sega Saturn, PlayStation
- The Simpsons
- Bart Simpson's Escape from Camp Deadly - Game Boy
- Bart's House of Weirdness - PC
- The Itchy and Scratchy Game - Genesis, SNES, Game Gear
- Krusty's Fun House - NES, SNES (as Krusty's Super Fun House), Game Boy, Game Gear
- The Simpsons - Arcade
- The Simpsons: Bart vs. the Space Mutants - Game Gear, Genesis, NES, PC
- The Simpsons: Bart vs. the World - Amiga, Game Gear, NES, Sega Master System
- The Simpsons Game - Wii, NDS, PlayStation 2, PlayStation 3, PlayStation Portable, Xbox 360
- The Simpsons Hit & Run - GameCube, PC, PlayStation 2, Xbox
- The Simpsons Road Rage - GameCube, PlayStation 2, Xbox
- The Simpsons Skateboarding - PlayStation 2
- The Simpsons Wrestling - PlayStation
- Virtual Bart - Super NES, Genesis
- Virtual Springfield - PC
- The Smurfs
- Revenge Of The Smurfs - Game Boy Advance
- Smurf: Rescue in Gargamel's Castle - Atari 2600, ColecoVision
- Smurfs Save the Day - (Atari 2600)
- Smurf: Paint 'n' Play Workshop - ColecoVision
- The Smurfs - NES, Master System, Game Boy, Mega Drive/Genesis, Game Gear, SNES, Mega CD, and Windows
- The Smurfs - Genesis, SNES
- The Smurfs Travel the World - Genesis, SNES
- The Smurfs - PlayStation
- Smurfs Nightmare - Game Boy Color
- Smurf Racer - PlayStation, Windows
- South Park
- South Park - PC, N64, PlayStation
- South Park: Chef's Luv Shack - Dreamcast, N64, PC, PlayStation
- South Park Rally - Dreamcast, N64, PC, PlayStation
- Space Goofs
- Stupid Invaders - PC, Dreamcast
- Speedy Gonzales
- Speedy Gonzales in Los Gatos Banditos - SNES
- Speedy Gonzales - Game Boy
- SpongeBob SquarePants
- SpongeBob SquarePants: Battle for Bikini Bottom - Game Boy Advance, GameCube, PC, PlayStation 2, Xbox
- SpongeBob SquarePants: Revenge of the Flying Dutchman - Game Boy Advance, GameCube, PlayStation 2
- SpongeBob SquarePants: SuperSponge - Game Boy Advance, PlayStation
- The SpongeBob SquarePants Movie - Game Boy Advance, GameCube, Mobile, PC, PlayStation 2, Xbox
- SpongeBob SquarePants: Legend of the Lost Spatula - Game Boy Color
- SpongeBob SquarePants Bowling - Mobile
- SpongeBob SquarePants Darts - Mobile, PC
- SpongeBob SquarePants: Creature from the Krusty Krab - Wii, PS2, GC, GBA, NDS, PC
- SpongeBob SquarePants: Employee of the Month - PC
- SpongeBob SquarePants: Krusty Kollection - PC
- SpongeBob SquarePants: Operation Krabby Patty - PC
- SpongeBob SquarePants: Lights, Camera, Pants! - PC, PS2, Xbox, GameCube, GBA, NDS
- SWAT Kats: The Radical Squadron
- SWAT Kats: The Radical Squadron - SNES
Read more about this topic: List Of Video Games Based On Cartoons