S
- Say it loud Teen Radio
- Sacred Heart Program
- The Sammy Kaye Show (1937–1956)
- Saturday Night Serenade (1936–1948)
- The Savage Nation with Michael Savage (2000–present)
- SCORE (306) Radio: Counselors to America's Small Business (1998–present) on WVOX
- Scattergood Baines (1938–1950)
- The Screen Guild Theater (1939–1952)
- The Sealed Book (1945)
- The Sean Hannity Show (nationally 2001–present)
- Second Husband (1937–1946)
- Second Mrs. Burton (1946–1960)
- Selected Shorts
- Sergeant Preston of the Yukon (1946–1955)
- Seth Parker (1929–1939)
- The Shadow (1937–1954)
- Shell Chateau (1935-1937)
- Silver Theatre (1937–1950)
- Sinfonietta (1935–1945)
- Singin' Sam (1930–1947)
- Singing Story Lady (1932–1941)
- Singin' Sam (1930–1947)
- The Six Shooter (1952–1954)
- *Sleep No More
- Smilin' Ed Maxwell Show (1932–1941)
- Smoke Dreams (1928–1946)
- Snow Village Sketches (1928–1947)
- The Sound of Young America
- The Southernaires Quartette (1930–1951)
- Space Patrol (1952–1955)
- The Sportsbash
- The Stan Freberg Show (1957)
- Stan Lomax (1935–1944)
- Star and the Story (1944)
- StarDate (1978-Date)
- Stella Dallas (1938–1955)
- Stoopnagle and Budd (1930–37)
- Story of Mary Marlin (1935–1952)
- Stop Me If You've Heard This One (1939–1948)
- Story Time (1929–1956)
- Strictly from Dixie (1941–1954)
- The Strange Dr. Weird (1944–45)
- Strike It Rich (1947–1957)
- Stroke of Fate (1953)
- Studio One
- Suspense (1942–1962)
- Swingin' Years (1956–2006)
Read more about this topic: List Of U.S. Radio Programs