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- Of Men and Books (1939–1948)
- Official Detective (1946–1957)
- Oklahoma City Symphony Orchestra (1949–1963)
- The Old-Fashioned Revival Hour (1936–1961)
- Old Gold on Broadway (1933–1948)
- On the Line with Bob Considine (1947–1963)
- One Man's Family (1932–1959)
- One Night Stand (1942–1962)
- The O’Neills (19343-1943)
- Open Forum (1961-2011)
- Open House Party (1988–present)
- The Opie & Anthony Show (1994–present)
- The Original Amateur Hour
- Our Gal Sunday (1937–1959)
- Our Miss Brooks (1948–1957)
- Our Secret Weapon (1942–1943), CBS Radio, counterpropaganda talk with Rex Stout
- Ozark Jubilee (1953–1960) on ABC Radio
Read more about this topic: List Of U.S. Radio Programs