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- Land of the Lost (1944–1948)
- The Landt Trio (1928–1951)
- The Lanny Ross Show (1929–1952)
- The Larry King Show (1978–present)
- The Lars Larson Show
- The Laura Ingraham Show (2001–present)
- The Lazlow Jones Show (through 2005)
- Leading Question (1953–1963)
- The Les Paul Show
- Let George Do It (1946–1955)
- Let's Dance (1934–1935)
- Let's Pretend (1937–1954)
- Life Can Be Beautiful (1938–1954)
- Life Online with Bob Parsons (2005–present)
- The Life of Riley (1944–1951)
- The Light of the World (1940–1950)
- Lights Out (1934–1947)
- The Linda Chavez Show
- Linda’s First Love (1939–1950)
- Little Orphan Annie (1931–1943)
- Live from the 60s with the Real Don Steele (1988–1993)
- The Lone Ranger (1933–1954)
- Longines Symphonette (1943–1958)
- Looking Over the Week (1933–1946)
- The Louella Parsons Show (1931–1951)
- Louisiana Hayride (1948–1958)
- Lone Journey (1940–1952)
- Long John Nebel
- Lorenzo Jones (1937–1955)
- Lowell Thomas and the News (1930–1976)
- Lum and Abner (1931–1953)
- The Lutheran Hour (1930–present)
- Lux Radio Theater (1934–1955)
Read more about this topic: List Of U.S. Radio Programs