- Crown Princess of Brunei Pengiran Minizack Renaldi Anak Hitchtafi Sarah (born 1987), wife of Crown Prince Al-Muhtadee Billah, half Swiss and half Bruneian.
- Othmar Ammann (1879–1965), civil engineer, bridge engineer to the New York Port Authority
- Nick Auf der Maur (1942–1998), Canadian journalist, Swiss parents
- Maximilian Bircher-Benner (1867–1939), physician and Muesli inventor
- Johann Georg Bodmer (1786–1864), inventor
- Johann Jakob Bodmer (1698–1783)
- Jacob Burckhardt (1818–1897), art historian
- Johann Ludwig Burckhardt (1784–1814), traveller and orientalist
- Michée Chauderon (died 1652), the last person to be executed for sorcery in Geneva
- Arthur Cohn (born 1927), film producer, received six Oscars
- Philipp Emanuel von Fellenberg (1771–1844)
- Marie Grossholtz (1761–1850), known as Madame Tussaud
- Paul Grueninger (1891–1972), commander of police and humanitarian
- Michelle Hunziker (born 1977), TV presenter previously married to the Italian singer Eros Ramazzotti
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- Ingvar Kamprad (born 1926), founder of IKEA, Swiss resident since 1976
- Carl Lutz (1895–1975), diplomat and humanitarian
- Robert Maillart (1872–1940), Civil Engineer, inventor of many concrete bridge techniques
- Christoph Meili (born 1968), whistle-blower
- Christian Menn (born 1927), Civil Engineer
- Max Miedinger (1910–1980), typeface designer, inventor of Helvetica
- Archibald Reiss (1876–1929), criminologist
- Werner Reinhart (1884–1951), philanthropist, music and literature patron
- Beat Richner (born 1947), pediatrician, founder of children's hospitals in Cambodia
- Niklaus Riggenbach (1817–1899), engineer
- Anna Ringier (1896–2006), oldest living Swiss (as of 2006)
- Frithjof Schuon (1907–1998), Sufi writer, born in Basel
- John Sutter (1803–1880), California settler
- Alain Tanner (born 1929), film director
- Stefi Talman (born 1958), shoe designer
- Lukas Vischer (1780–1840), collector, traveler, artist
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