Middle East and North Africa
- Abbasid Caliphate - An-Nasir, Caliph of Baghdad (1180–1225)
- Emirate of Aleppo - Al-Aziz (1216–1236)
- Almohad Caliphate - Abu Ya'qub Yusuf II (1213–1224)
- Principality of Antioch - Bohemond IV (1219–1233)
- Armenian Kingdom of Cilicia - Isabella (1219–1252)
- Ayyubid Sultanate - Al-Kamil, Sultan of Egypt (1218–1238)
- Byzantine Empire - in exile in the Empire of Nicaea - Theodore I Lascaris (1204–1222)
- Kingdom of Cyprus - Henry I (1218–1253)
- Sultanate of Damascus - Al-Mu'azzam (1218–1227)
- Kingdom of Georgia - Giorgi IV Lasha (1213–1223)
- Emirate of Hamah - Al-Mansur I (1191–1221)
- Emirate of Homs - Al-Mujahid (1186–1240)
- Kingdom of Jerusalem (in Acre) - Yolande (1212–1228) (John of Brienne, regent, 1212–1225)
- Latin Empire of Constantinople - Conon of Bethune, regent (1219–1221) in the absence of Robert of Courtenay
- Sultanate of Rûm
- Kaykaus I (1211–1220)
- Kayqubad I (1220–1237)
- The Jezirah - Al-Ashraf (1218–1237)
- Empire of Trebizond - Alexius I (1204–1222)
- County of Tripoli - Bohemond IV (1219–1233)
- Emirate of Yemen - Al-Mas'ud Yusuf (1215–1229)
Read more about this topic: List Of State Leaders In 1220
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