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- Robert Schumann, German composer
- Nina Simone, American singer. Interview with her daughter Simone, The Sunday Times June 24, 2007
- Frank Sinatra, American singer and actor. "Being an 18-karat manic depressive, and having lived a life of violent emotional contradictions, I have an over-acute capacity for sadness as well as elation."
- Michael Slater, International Australian cricketer, forced to retire because of related symptoms.
- Tony Slattery, actor and comedian. "I rented a huge warehouse by the river Thames. I just stayed in there on my own, didn't open the mail or answer the phone for months and months and months. I was just in a pool of despair and mania." BBC Documentary
- Sidney Sheldon, producer, writer; wrote about being a victim of bipolar disorder in his autobiography The Other Side of Me.
- Tim Smith, rugby league player whose career with NRL side Parramatta Eels was ended due to his bipolar condition, and pressure from the media.
- Alonzo Spellman, American football player
- Peter Steele, frontman, Type O Negative.
- David Strickland, Actor, Suddenly Susan.
- Poly Styrene (real name Marion Elliot-Said), singer.
- Stuart Sutherland, British psychologist and writer
Read more about this topic: List Of People With Bipolar Disorder