Athletics
- Randy Barnes (b. 1966), professional shot putter, born in Charleston
- Larry Barnett (b. 1945), professional baseball umpire, born in Nitro
- Clair Bee, college basketball coach
- Vern Bickford, professional baseball player
- Terry Bowden, college football analyst and commentator
- Tommy Bowden, college football coach
- Brian Bowles, UFC/MMA fighter
- Rich Braham, professional football coach
- George Brett, professional baseball player
- Lew Burdette, professional baseball player
- Jesse Burkett, professional baseball player
- Necro Butcher, professional wrestler
- Eddie Cameron, college basketball coach
- Mark Canterbury, professional wrestler
- Bimbo Coles, professional basketball player
- Wilbur Cooper, professional baseball player
- Larry Coyer, professional football coach
- Dan D'Antoni, professional basketball coach
- Mike D'Antoni, professional basketball player and coach
- Jack Dempsey, professional boxer
- Jimbo Fisher, college football coach
- Gene Freese, professional baseball player
- Frank Gatski, professional football player
- Hal Greer, professional basketball player
- Cam Henderson, college football, basketball, and football coach
- Lou Holtz, college football coach
- Jeff Hostetler, professional football player
- J. R. House, professional baseball and football player
- Chuck Howley, professional football player
- Sam Huff, professional football player
- Bob Huggins, college basketball coach
- Hot Rod Hundley, professional basketball player and broadcaster
- Dwayne Jones, professional basketball player
- John Kruk, professional baseball player
- Doug Legursky, professional football player
- Gino Marchetti, professional football player
- Chris Massey, professional football player
- O.J. Mayo, professional basketball player
- Bill Mazeroski, professional baseball player
- Leo Mazzone, professional baseball player
- Seth McClung, professional baseball player
- Renee Montgomery, professional women's basketball player
- Randy Moss, professional football player
- Dustin Nippert, professional baseball player
- Jamie Noble, professional wrestler (WWE)
- Patrick Patterson, professional basketball player
- Joe Pettini, professional baseball coach
- Kevin Pittsnogle, college basketball player
- Mary Lou Retton, professional gymnast
- Nick Saban, professional and college football coach
- Ben Schwartzwalder, Hall of Fame college football coach
- Heath Slater, professional wrestler (WWE)
- Tamar Slay, professional basketball player
- Stephanie Sparks, professional golfer and commentator
- Emanuel Steward, boxing trainer
- Bill Stewart, ex. head football coach of the West Virginia Mountaineers
- Nick Swisher, professional baseball player
- Rick Tolley, college football coach
- Rod Thorn, professional basketball player
- Bill Walker, professional basketball player
- Curt Warner, professional football player
- Jerry West, professional basketball player
- Deron Williams, professional basketball player
- Jason Williams, professional basketball player
- Steve Yeager, professional baseball player
- Fielding H. Yost, college football coach
Read more about this topic: List Of People From West Virginia