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- Elliott Sadler(born 1975) – NASCAR driver
- Bob Saget (born 1956) § – actor and comedian, current host of 1 vs. 100; best known for his role as Danny Tanner on the 1987–95 series Full House as well as the original host of America's Funniest Home Videos
- Billy Sample (born 1955) MLB player who played for the Texas Rangers, New York Yankees, and Atlanta Braves
- Rick Santorum (born 1958) – lawyer and former U.S. Senator from Pennsylvania
- Joe Saunders (born 1981) – starting pitcher for the Baltimore Orioles
- Owen Schmitt (born 1985) § – fullback for the Philadelphia Eagles
- Ed Schultz (born 1954) – left wing TV/radio host, The Ed Show
- Michael Schwimer (born 1986), relief pitcher for the Philadelphia Phillies
- George C. Scott (1927–1999) – actor who won an Oscar for portraying George Patton
- Wendell Scott (1921–1990) – first African-American to race in NASCAR.
- Willard Scott (born 1934) – former weather reporter on The Today Show; earlier, was the original Ronald McDonald
- Winfield Scott (1786–1866) – United States Army general
- Seka (born 1954) Legendary International Adult Film Star
- Steve Scully (born 1960) – host of C-SPAN's Washington Journal
- Tom Shadyac (born 1958) – film director, Liar Liar, Bruce Almighty, The Nutty Professor
- Darren Sharper – retired NFL safety
- Meghann Shaughnessy – professional tennis player
- Deborah Shelton – actress, Miss USA 1970
- Ricky Van Shelton – country music/gospel singer, Altavista
- John Wesley Shipp – actor, Dawson's Creek, The Flash, Guiding Light
- Clint Sintim – linebacker for the New York Giants
- Scott Sizemore – infielder for the Oakland A's
- Sam Sloan (born 1944) – political prisoner, kidnapping victim
- Bruce Smith (born 1963) – former NFL star and career sack leader
- Joe Smith (born 1975) – NBA player for the L.A. Lakers
- John Smith of Jamestown § (1580–1631) – co-founder of Jamestown Settlement, 1st English colony in America (1607)
- Kate Smith (1909–1986), Singer
- Torrey Smith – wide receiver for the Baltimore Ravens
- Norm Snead (July 31, 1939–)- a former American football quarterback in the National Football League for the Washington Redskins, Philadelphia Eagles, Minnesota Vikings, New York Giants, and San Francisco 49ers.
- Jason Snelling § (born 1983) – running back for the Atlanta Falcons
- John W. Snow – former United States Secretary of the Treasury and former Chairman and Chief Executive Officer of CSX Corporation
- Maura Soden (born 1955) – actress
- Trey Songz (born 1984) – singer
- Scott Sowers (born 1963) – actor
- Ralph Stanley (born 1927) – musician
- Robert Stanton § (born 1963) – actor, The Cosby Mysteries
- Robert Stethem § (1961–1985) – U.S. Navy Seabee diver killed by Hezbollah militants during the hijacking of TWA Flight 847
- Brandon Stokley (born 1976) – wide receiver for the Seattle Seahawks
- Julyan Stone (born 1988) – player for the Denver Nuggets
- Jessica Mae Stover – actor, filmmaker, author
- J.E.B. Stuart (1833–1864) – Confederate military leader
- William Styron (1925–2006) – novelist
- Skipp Sudduth § (born 1956) – actor, John 'Sully' Sullivan on Third Watch
- Margaret Sullavan (1909–1960), actress
- Wanda Sykes – comedian, born in Portsmouth, Virginia
Read more about this topic: List Of People From Virginia