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- Kenny Easley (born 1959) – College Football Hall of Fame safety for the Seattle Seahawks
- Elizabeth Edwards § (1949–2010) – attorney, author, estranged wife to John Edwards
- Missy Elliott (born 1971) – rapper
- Perry Ellis (March 3, 1940 – May 30, 1986) Fashion designer.
- Brother Claude Ely (1922–1978) – singer, songwriter, Pentecostal Holiness preacher
- Garrett Epps (born 1950) – legal scholar, novelist, journalist
- Victoria Espinel (born 1968) – Intellectual Property Enforcement Coordinator under Barack Obama
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