S
- Dwight M. Sabin § (1843–1902) – U.S. Senator
- Martin Olav Sabo § (born 1938) – former member of U.S. Congress
- Harrison Salisbury (1908–1993) – journalist
- Zak Sally – musician
- Ralph Samuelson (1903–1977) – inventor of water skiing, first water-ski jumper and speed skier
- John B. Sanborn (1826–1904) – Union Army General, state legislator
- John B. Sanborn, Jr. (1883–1964) – Eighth Circuit Court of Appeals Judge
- Tony Sanneh (born 1971) – soccer player
- Johan Santana (born 1979) – baseball player
- Gary Sargent (born 1954) – hockey player
- Gloria Sawai (Gloria Ruth Ostrem) (born 1932) – author of fiction
- Thomas D. Schall § (1878–1935) – U.S. Senator; member of U.S. Congress
- Bruce Schneier (born 1963) – founder and CTO of Counterpane Internet Security
- Henry Schoolcraft § (1793–1864) – explorer
- Charles M. Schulz (1922–2000) – cartoonist
- Richard M. Schulze – founder and chairman of Best Buy
- Mae Schunk § (born 1934) – 45th Lieutenant Governor of Minnesota
- Seann William Scott (born 1976) – actor
- Kathryn Leigh Scott (Kathryn Kringstad) (born 1945) – author, actor
- Todd Scott – football player
- Briana Scurry (born 1971) – soccer player
- Richard Warren Sears (1863–1914) – co-founder of Sears, Roebuck and Company
- Mitch Seavey – dog musher
- Jerry Seeman – National Football League referee and Director of Officiating
- Robert Seguso (born 1963) – tennis player
- Aaron Sele (born 1970) – baseball player
- Conrad Selvig (1877–1953) – member of U.S. Congress
- Joe Senser – football player
- Marty Sertich (born 1982) – hockey player
- Brian Setzer §
- Eric Sevareid § (1912–1992) – television journalist
- Eddie Sharkey – wrestling coach
- Darren Sharper (born 1975) – football player
- Michaela Shapero (born 1997) - National & MN State Archery medalist
- Clark Shaughnessy (1892–1970) – football coach
- Sam Shepard - actor; lived in Stillwater, MN with partner Jessica Lange
- Charles D. Sherwood – 4th Lieutenant Governor of Minnesota
- James Shields § (1810–1879) – U.S. Senator
- Henrik Shipstead (1881–1960) – U.S. Senator
- Francis Shoemaker (1889–1958) – member of U.S. Congress
- Bob Short (1917–1982) – sport teams owner and politician
- Henry Hastings Sibley § (1811–1891) – 1st Governor of Minnesota
- Christopher Sieber (born 1969) – actor
- Dick Siebert § (1912–1978) – college baseball coach
- Gerry Sikorski (born 1948) – member of U.S. Congress
- Clifford D. Simak § (1904–1988) – science-fiction writer
- Richard Simmons (1913–2003) – actor
- George Sitts – convicted murderer
- Slug (born 1973) – rapper
- Roy Smalley § (born 1952) – baseball player
- Jack Smight (1925–2003) – film director
- Bruce Smith (1920–1967) – Heisman Trophy winner
- Chad Smith (born 1961) – Drummer for the Red Hot Chili Peppers
- Edward Everett Smith 18th Lieutenant Governor of Minnesota
- George Ross Smith (1864–1952) – member of U.S. Congress
- Larry H. Smith (1939–2002) – hockey player
- Lyndon Ambrose Smith 15th Lieutenant Governor of Minnesota
- Onterrio Smith § (born 1980) – football player
- Phillips Waller Smith (1906–1963) – U.S. Air Force Major General
- Raonall Smith (born 1978) – football player
- Robert Smith § (born 1972) – football player
- Wyatt Smith (born 1977) – hockey player
- Fred Smoot § (born 1979) – football player
- Josiah Snelling § (1782–1828) – first commander of Fort Snelling
- Samuel Snider § (1845–1928) – member of U.S. Congress
- Ben Sobieski (born 1979) – football player
- Konrad K. Solberg 27th Lieutenant Governor of Minnesota
- Kathleen Soliah § (born 1947) – member of the Symbionese Liberation Army
- Gordon Solie (Francis Jonard Labiak) (1929–2000) – wrestling announcer
- Jesse Solomon – football player
- Spenser J. Somers § (1972–1990) – author
- Rich Sommer § (born 1978) – actor
- Stephen Sommers § (born 1962) - director
- Gale Sondergaard (1899–1985) – Academy Award winning actress (1936)
- Kevin Sorbo (born 1958) – actor
- Richard K. Sorenson (1924–2004) – sailor
- Ann Sothern (1909–2001) – actress
- Matt Spaeth – football player
- Allan Spear § (1937–2008) – state legislator and president of the Minnesota Senate
- LaVyrle Spencer – romance novelist
- Lili St. Cyr (Willis Marie Van Schaack) (1918–1999) – ecdysiast
- Paul St. Peter (born 1958) – (Aka. George C. Cole and Francis C. Cole) – voice actor
- Arlan Stangeland § (born 1930) – member of U.S. Congress
- Maurice Stans (1908–1998) – U.S. secretary of commerce
- Frank Starkey (1892–1968) – member of U.S. Congress
- Harold Stassen (1907–2001) – 25th Governor of Minnesota
- Ozora P. Stearns § (1831–1896) – U.S. Senator
- Franklin Steele § (1813–1880) – Early settler of St. Anthony
- Halvor Steenerson § (1852–1926) – member of U.S. Congress
- Andy Steensma (born 1942) – farmer, mayor, politician
- Heidemarie M. Stefanyshyn-Piper (born 1963) – astronaut
- Will Steger (born 1943) – polar explorer
- Terry Steinbach (born 1962) – Major League Baseball player
- Helen Stenborg (born 1925) – actor
- Phil Sterner (born 1960) – politician
- Cliff Sterrett – cartoonist
- Todd Steussie – football player
- Frederick Stevens § (1861–1923) – member of U.S. Congress
- John H. Stevens – § (1820–1900) first civilian (non-indigenous) resident of Minneapolis
- Jacob H. Stewart § (1829–1884) – member of U.S. Congress
- Bob Stinson (Robert Neil Stinson) (1959–1995) – musician
- Tommy Stinson (born 1966) – musician
- Carl Stockdale (1874–1953) – actor
- Cal Stoll (1923–2000) Former ACC coach of the year/ Wake Forrest Football, University of MN head coach
- Erik Stolhanske (born 1968) – comedian
- Horace B. Strait § (1835–1894) – member of U.S. Congress
- Korey Stringer § (1974–2001) – football player
- Charles Strite – inventor of the modern pop-up toaster
- Eric Strobel (born 1958) – hockey player, 1980 Miracle on Ice hockey-team member
- Mike Stuart (born 1980) – hockey player
- Scott Studwell – football player
- Terrell Suggs – football player
- George H. Sullivan – 21st Lieutenant Governor of Minnesota
- Clinton Sundberg – actor
- Milt Sunde – football player
- David C. Sutherland III (1949–2005) – Dungeons & Dragons artist
- Steve Sviggum – politician
- Curt Swan (1920–1996) – comic book artist
- Lori Swanson (born 1966) – Minnesota Attorney General
- Nick Swardson (born 1977) – stand-up comedian, actor
- Henry Adoniram Swift § (1823–1869) – 3rd Governor of Minnesota and 3rd Lieutenant Governor of Minnesota
- William Irvin Swoope § (1862–1930) – lawyer and politician
Read more about this topic: List Of People From Minnesota