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- Tim Irwin – football player
- Barney Irwin – wrestler
- Scott Irwin (born 1952) – wrestler
- Doran Isackson (1938–1989) – politician, farmer
- Sharon Isbin (born 1956) – classical guitarist
- Dan Israel – musician
- I Self Devine (born 1972) – musician
- Ishtakhaba – Lakota chief
- Gideon S. Ives – 11th Lieutenant Governor of Minnesota
Read more about this topic: List Of People From Minnesota