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- John Cariani, actor, Law & Order; grew up in Presque Isle
- Howie Carr, journalist, author, radio talk-show host; born in Portland
- Bill Carrigan (1883–1969); catcher and manager for the Boston Red Sox; born in Lewiston
- Josh Casaubon (born 1978), actor, Hugh Hughes on One Life to Live; born in Brunswick
- Joshua Chamberlain (1828–1914); American Civil War Major General, Governor of Maine (1867–71)
- Conrad Chase (born 1965), actor, singer; born in Portland
- Frank Churchill (1901–1942); Oscar-winning composer for many Disney animated films; born in Rumford
- William Cohen (born 1940); US Congressman (1973–79), Senator (1979–97), US Secretary of Defense (1997–2001); born in and Mayor (1971–73) of Bangor
- Samuel Colman (1832–1920); artist, writer, interior designer; born in Portland
- Robert P Collins (born 1988); Professional dancer from Maine; born in China
- Susan Collins (born 1952); U.S. Senator from Maine; born in Caribou
- Ricky Craven (born 1966); ESPN broadcaster, NASCAR driver, born in Newburgh
- Ian Crocker (born 1982); three-time Olympic champion in swimming; born in Portland
- Earl Cunningham (1893–1977); folk artist
Read more about this topic: List Of People From Maine