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| Larry Sanger | 1968 | living | Anchorage | co-founder of Wikipedia |
| Curt Schilling | 1966 | living | Anchorage | professional baseball player |
| Daniel Schlereth | 1986 | living | Anchorage | professional baseball player |
| Mark Schlereth | 1966 | living | Anchorage | professional football player, football analyst for ESPN |
| Brian Schmidt | 1967 | living | Anchorage | astrophysicist, 2011 Nobel Prize laureate in Physics |
| Mitch Seavey | living | Seward, Sterling | sled dog racer | |
| Charles John Seghers | 1839 | 1886 | Juneau, Nulato, Sitka | pioneering Catholic missionary |
| Ronald Senungetuk | 1933 | living | Fairbanks, Homer, Wales | silversmith, sculptor |
| Leonhard Seppala | 1877 | 1967 | Fairbanks, Nome | sled dog racer, key musher in the 1925 serum run to Nome |
| Tom Sexton | 1940 | living | Anchorage, Fairbanks | poet, former Alaska poet laureate |
| Don Simpson | 1943 | 1996 | Anchorage | Hollywood film producer |
| Jamie Smith | ca. 1965 | living | Fairbanks | cartoonist, printmaker |
| Molly Smith | living | Douglas | theater director | |
| Soapy Smith | 1860 | 1898 | Skagway | con artist, gangster |
| Steve Smith | 1985 | living | Anchorage | St. Louis Rams football player |
| Dana Stabenow | 1952 | living | writer | |
| Darby Stanchfield | 1971 | living | Kodiak, Unalaska | television actress |
| Ted Stevens | 1923 | 2010 | Anchorage, Fairbanks, Girdwood | both the longest-serving U.S. Senator from Alaska and from the Republican Party |
| John Strohmeyer | 1924 | 2010 | Anchorage | Pulitzer Prize-winning journalist; journalism professor at the University of Alaska Anchorage, where he wrote several books about Alaska, including Extreme Conditions |
| John F. A. Strong | 1856 | 1929 | Iditarod, Juneau, Katalla, Nome, Skagway | founder of what is now the Juneau Empire, territorial governor |
| Robert Stroud | 1890 | 1963 | Juneau | convicted killer, later better known as "The Birdman of Alcatraz" |
| Stephen Sundborg | living | president of Seattle University | ||
| Rick Swenson | 1950 | living | Manley Hot Springs, Two Rivers | sled dog racer |
| Jim Sykes | 1950 | living | Anchorage, Palmer, Talkeetna | Green Party politician |
Read more about this topic: List Of People From Alaska