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- Gabriela Rejala, Miss World 2008
- Alba Riquelme, beauty queen and model.
- Blas Riquelme, politician, businessman and landowner
- Larissa Riquelme, model and actress, named "Girl of the FIFA 2010 World Cup"
- Augusto Roa Bastos, writer
- Andrés Rodríguez, army general and former president
- Hugo Rodríguez-Alcalá, writer
- José Gaspar Rodríguez de Francia, first Paraguayan head of government
Read more about this topic: List Of Paraguayans