Pre-1700
- June 1526 – A Spanish brigantine is lost off Wilmington.
- June 14, 1566 – Two vessels in the Spanish fleet of Ángel de Villafañe sink off Cape Hatteras, which is believed to have been caused by a hurricane.
- June 23–June 26, 1586 – A powerful hurricane threatens the fleet of Sir Walter Raleigh in Roanoke Island; its passage influences the settlers to return with Raleigh to England.
- August 31, 1587 – A hurricane passes near or over Roanoke Island, causing rough seas for the fleet of Sir Walter Raleigh.
- August 1590 – John White leads a survey to discover the remains of the Roanoke Colony, but is forced to leave due to an approaching hurricane.
- August 26, 1591 – Strong winds from a hurricane prevent a sailing expedition along the coastline.
- September 6, 1667 – Many buildings are destroyed in association with a hurricane that strikes the northern Outer Banks, which also causes some crop damage.
- August 18, 1669 – A hurricane crosses the northern Outer Banks.
- August 6, 1670 – The Outer Banks are affected by a hurricane.
Read more about this topic: List Of North Carolina Hurricanes (pre-1900)