S
- Humberto Sánchez
- Amado Samuel
- Juan Samuel
- Alejandro Sánchez
- Duaner Sánchez
- Félix Sánchez
- Jesús Sánchez
- Andrés Santana
- Carlos Santana
- Ervin Santana
- Julio Santana
- Marino Santana
- Rafael Santana
- Ramón Santiago
- Francisco Santos
- Víctor Santoso
- Luis Saturria
- José Segura
- Wascar Serrano
- Luis Silverio
- Tom Silverio
- Julio Solano
- Alfonso Soriano
- Rafael Soriano
- Elías Sosa
- Jorge Sosa
- José Sosa
- Juan Sosa
- Sammy Sosa
- Mario Soto
- William Suero
Read more about this topic: List Of Major League Baseball Players From The Dominican Republic