S
- Sabrina and the Harvetones - Sabrina's Secret Life
- The Sacred Cows - Get Smart
- Sacred Death - Everybody Loves Raymond
- Sadgasm - The Simpsons
- Saltwater Sam featuring The Brine Brothers - SpongeBob Squarepants
- The Sandy Bottom Orchestra - The Sandy Bottom Orchestra
- Santa Kläws - Mystery Science Theater 3000
- Maya Santos - Maya & Miguel
- Satan's Night Out - The Vampire Lestat, Queen of the Damned (film)
- Satan's Penis - The Drew Carey Show
- The Saturn 5 - That Thing You Do!
- Sausalito - Lost In Translation
- Satine - Moulin Rouge!
- Saucer People - Lizzie McGuire
- Savante - madTV
- The Savages - Degrassi Junior High & Degrassi High
- Scab - Home Movies
- Scare Tactics - Scare Tactics (DC Comics)
- Scarecrow Boat - Parks and Recreation
- Scat Cat's Band - The Aristocats
- School of Rock - School of Rock
- Glen Schoolbell - ] April 1997 I Was Country When I Was In School Pull Out Prank CD cover
- Scrambled Debutante - Calvin and Hobbes
- Scrantonicity - The Office
- The Screaming Banshees - The Paper Brigade
- Schreibmaschin - Sprockets (Saturday Night Live)
- Willie Scott - Indiana Jones and the Temple of Doom
- Scum of the Earth - WKRP in Cincinnati
- Sean Harrison - Jem
- Sean Harrison and The Boys - Jem
- Séance - Shaman King
- Seaweed Sally and Her Cackling Turtle - SpongeBob Squarepants
- Sebastian Grace and The Electric Insects - Life On Mars
- The Secret Three - The Secret Three, Nickelodeon Magazine comic
- Sgt. Pepper's Lonely Hearts Club Band - Beatles' album Sgt. Pepper's Lonely Hearts Club Band
- Sgt. Pepper's Lonely Hearts Club Band - Sgt. Pepper's Lonely Hearts Club Band (1978 film)
- Sgt. Pepper's Lonely Hearts Club Band - Yellow Submarine
- Sgt. Rutter's Only Darts Club Band - All You Need Is Cash
- Chrissy Seaver - Growing Pains: Return of the Seavers
- Several Thousand Dollars in Motion - Achewood
- Severe Tyre Damage - Mrs Doubtfire (not to be confused with the real Severe Tire Damage)
- Sewernose D'vorgac - Chip 'n Dale Rescue Rangers
- Sex Bob-omb - Scott Pilgrim
- Sex Funeral - Achewood
- Sexual Chocolate - Coming to America
- The Sexual Homeboys - Achewood
- The Sharks - A Clockwork Orange
- Sharon Apple - Macross Plus
- Shasta McNasty
- Sheryl Nome - Macross Frontier
- Shiny Money - Austin and Ally
- Shoe 2 - Bizarro
- Simon Leeds - Just Shoot Me!
- Abraham Simpson - The Simpsons
- Bart Simpson - The Simpsons
- Homer Simpson - The Simpsons
- Lisa Simpson - The Simpsons
- Marge Simpson - The Simpsons
- The Simpsons - The Simpsons
- Sissy Sullivan - Shame
- Sister Mary Margaret Mayhem - Inventions musical birthday card
- Sisters of Mercy Hold No Pain Against The Dark Lord - South Park
- Stephanie Shipper - Friends
- Shit - Joe's Apartment
- The Shitty Beatles - Wayne's World
- Shoes 'n Socks - Married...With Children
- Short Angry Freuds - The Life and Times of Juniper Lee
- The Short Circus - The Electric Company
- Steven Shorter - Privilege
- Shoyu Weenie - Harvey Birdman: Attorney at Law
- Gordo Shumway - Alf Tales
- Sick Dick and the Volkswagens - The Crying of Lot 49
- Sidekix - Top 10
- Silly Rabit - Mission Hill
- The Silver Herringbones - "The Andy Griffith Show - S08E26"
- S1m0ne
- The Sirens - Shake, Rattle and Rock! (1994)
- Sister and The Sisters - Sparkle
- Sister Oma and The Clarions - UFOria
- Skaface - This Is Spinal Tap
- Skalle- Bones, "Mayhem On The Cross""
- The Skulls - Jem
- Chip Skylark - Fairly Oddparents
- The Slags - The Comic Strip
- Sled Dog Afterbirth - Hard Core Logo
- The Sleazoids - Bionic Six
- The Sleez Sisters – Times Square
- Candy Slice - Saturday Night Live
- Slipdog - My Guide to Becoming a Rockstar
- The Slip Nuts - Late Night with Conan O'Brien
- Sloshy - Homestar Runner
- Sludge - Guitar Girl
- Smash - The Elephant Princess
- Smeg and The Heads - Red Dwarf
- R. Smelly - Nickelodeon Magazine May 1997 "Sing-a-Wrong"
- Hayley Smith - American Dad
- Postmaster P. Smith - Leprechaun: In The Hood
- The Smokey Mountain Laurels - Nashville
- Raymond Quentin Smuckles - Achewood
- Snakes N Barrels- Former band of Pickles the Drummer Metalocalypse
- Snoop Kitty Kitty - Round House, parody of Snoop Doggy Dogg
- Snoutra - Space Goofs
- Aldous Snow - Forgetting Sarah Marshall, Get Him To The Greek
- Nuke Sour - Nickelodeon Magazine May 1998, "Leonardo DiCaprio Quiz"
- The Southern Fried Fugitives - Nickelodeon Magazine November 1995 The New Adventures of the Southern Fried Fugitives
- The Space Cadets - Jem
- The Sparkplugs - Jem comics Special #1 "Opportunity Knocks"
- Spew - Bones, Mayhem On The Cross"
- Spewing Pheasants - Round House
- Spiked Earlobes - Saved By The Bell
- Spoink - Lizzie McGuire
- So Smite - Jem (shown on record in Kimber's Rebellion)
- Society For Creative Rock Anachronism - Questionable Content
- The Sock Pastilles - Soul Music animated series (called Insanity, etc. in the book)
- The Soggy Bottom Boys - O Brother, Where Art Thou
- Solid Foam - The Jim Henson Hour
- The Sonars - SpongeBob SquarePants
- Sonic & Knuckles - Scott Pilgrim
- Sonic Underground
- Sonic Death Monkey - High Fidelity
- Sons of Butcher - Sons of Butcher
- Sons of Lee Marvin - Guitar Girl
- The Sons of Thunder - Airheads
- The Sorels - Streets of Fire
- Sparkle Motion - Donnie Darko
- Robin Sparkles - How I Met Your Mother
- Skip Sparkypants - Fairly Oddparents
- Spatzal! - Molvania's most successful pop music act
- Spectacular - Spectacular!
- Spice Boys - Late Night with Conan O'Brien
- The Sparks - Drake and Josh
- Spidorr - Mystery Science Theater 3000
- Spinal Tap - This is Spinal Tap
- The Spinning Topps - Sliders
- Spittle - Bandwagon
- SpongeBob and the Losers - SpongeBob SquarePants
- Dino Spumoni - Hey Arnold!
- Squatting Camels - Round House
- Mick Stagger - Nickelodeon Magazine March 1998, "Make The Band"
- The Stainless Steel Rats - The Stainless Steel Rat Sings the Blues
- The Stains - Ladies and Gentlemen, The Fabulous Stains
- The Standells - The Munsters
- Ringo Starched - Nickelodeon Magazine March 1998, "Make The Band"
- Static Moss - Jem
- Steel Dragon - Rock Star
- Johnny Steele - Critters
- Stephen and the Colberts - - The Colbert Report
- Derek Stevens - played by Dana Carvey on Saturday Night Live
- Stillwater - Almost Famous
- The Stingers - Jem
- Stingray 5000 - SpongeBob SquarePants
- Stewie and The Cowtones - Family Guy
- Stoker - Sliders
- Chad Stone - Quantum Leap
- Johnny Stone - Jem
- Stone Cyphers - X-Men: Evolution
- Red Stovall - Honkytonk Man
- Strange Fruit - Still Crazy
- Strawberry Jam - Strawberry Shortcake (2009)
- Stray Bullet - Leprechaun: In The Hood
- The Street Frogs - The Comic Strip, Street Frogs
- Street Slim - The Blues Brothers
- Strontium Goat - First Among Sequels
- Stüds- "Degrassi: The Next Generation"
- Songfellow Strum - The Care Bears
- Johnny Suede
- The Suedes - Happy Days
- The Sugar Boyz - The Mighty B!
- The Sulky Boys - All Grown Up
- The Sultans of Swing - Dire Straits song "The Sultans of Swing", Brothers In Arms album
- Super - The Scooby Doo Show
- The Super Head Shrinkers - Visa credit card commercial
- Sushi K - Snow Crash
- The Swanky Modes - Tapeheads
- Avianne Swansong - Nickelodeon Magazine October 2000, Ruffing It Episode 34 "Revenge Is Tweet"
- Sweaty Keith - Saturday Night Live, "New Jack Thanksgiving", parody of Keith Sweat
- The Sweeney Sisters - Saturday Night Live
- Sweet Sue and Her Society Syncopators - Some Like It Hot
- The Swing Kings - Friends, "The One With Chandler and Monica's Wedding"
- Sylk - Glitter
- Trey Sylvania - I Kissed A Vampire
- Moe Szylack - The Simpsons
Read more about this topic: List Of Fictional Music Groups