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- Shanna O'Callahan - The Real Ghostbusters
- The Oaktag Boys -] April 1997 I Was Country When I Was In School Pull Out Prank CD cover
- Obelisks - Dieter's Dance Party, Saturday Night Live
- Ocean Bottom Nightmare Band - Sealab 2021
- Oh Boyz - Kim Possible
- Denis O'Bell - from You Know My Name by The Beatles
- Malcom O'Dell - from the TV show My Two Dads. Portrayed by Davy Jones.
- Outta Sync - The Adventures of Jimmy Neutron: Boy Genius
- Octo Raymond and His All Mollusk Orchestra - The Tick
- ODB and the Last Stands - Hot Club de Paris: The Rise and Inevitable Fall of the High School Suicide Cluster Band.
- Oedipus and the Momma's Boys - P.C.U.
- The Old Rocker - Austin and Ally
- The Oliver Twists (later The Twists) - DC Comics Batman and All New Atom
- Omar and The Daycares - Rock and Rule
- The Oneders (later The Wonders) - That Thing You Do!
- The Oooh La La Las - Angela Anaconda
- Operaman - Saturday Night Live
- The Oreos - A Star is Born
- The Orange Organics - Pugwall
- The Originals - This Is Spinal Tap
- Ortega - Murder, She Wrote
- The Ossians - "The Ossians" by Doug Johnstone
- Clark Otis - American Hot Wax
- The Outcasts - Jem comics #9 "Hidden Message"
- Omega & The Mechanical Animals - Marilyn Manson's Mechanical Animals
- Otis Day and the Knights - Animal House
- Otitis Media - Married... With Children
- Ozzie and the Cobblepots - The Batman
Read more about this topic: List Of Fictional Music Groups