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| Name | Life | Profession | Cause of death | Reference |
|---|---|---|---|---|
| George Sanders | 1906–1972 | Actor | Nembutal overdose. Suicide. | |
| John Saunders | 1954–1999 | Musician (Mad Season) | Heroin overdose. | |
| Catya Sassoon | 1968–2002 | Model, actress | Hydromorphone and cocaine overdose. | |
| Sonja Savić | 1961–2008 | Actress | Unspecified drug overdose. | |
| Sybille Schmitz | 1909–1955 | Actress | Sleeping pill overdose. Suicide. | |
| Bon Scott | 1946–1980 | Musician (AC/DC) | Official cause of death listed as "acute alcohol poisoning". | |
| Ronnie Scott | 1927–1996 | Jazz tenor saxophonist | Prescription barbiturate overdose. Accidental. | |
| Pat Screen | 1943–1994 | American football player | Unspecified drug overdose. | |
| Rod Scurry | 1956–1992 | Major League Baseball pitcher | Cocaine-induced heart attack. | |
| Jean Seberg | 1938–1979 | Actress | Barbiturate and alcohol overdose. Suicide. | |
| Chantal Sébire | 1955–2008 | Teacher | Pentobarbital overdose. Euthanasia. | |
| Edie Sedgwick | 1943–1971 | Actress | Barbiturate and alcohol overdose. Undetermined. | |
| Bobby Sheehan | 1968–1999 | Musician (Blues Traveler) | Unspecified drug overdose. | |
| Eric Show | 1956–1994 | Baseball player | Cocaine and heroin overdose. | |
| Elizabeth Siddal | 1829–1862 | Model, poet, artist | Laudanum overdose. | |
| Judee Sill | 1944–1979 | Musician | Cocaine and heroin overdose. | |
| Don Simpson | 1943–1996 | Film producer | Cocaine-induced heart attack. Twenty other drugs were found in his blood. | |
| Tom Simpson | 1937–1967 | Cyclist | Dehydration and exhaustion while cycling exacerbated by amphetamines and alcohol use. | |
| Hillel Slovak | 1962–1988 | Musician (Red Hot Chili Peppers) | Heroin overdose. | |
| Alvim Smith | 1798–1823 | Carpenter's assistant | Mercury(I) chloride overdose. Officially administered to cure bilious colic; speculated murder. | |
| Daniel Smith | 1986–2006 | Student, Anna Nicole Smith's son | Cardiac dysrhythmia caused by combination of methadone, Lexapro and Zoloft. | |
| Corey Smoot aka. Flattus Maximus | 1977–2011 | Guitarist | Coronary artery thrombosis related to cocaine and opiate use. | |
| Dash Snow | 1981–2009 | Artist | Heroin overdose. | |
| Robert Soblen | 1900–1962 | Psychiatrist | Barbiturate overdose. | |
| Erin Spanevello | 1987–2008 | Fashion model | Overdose of MDMA and GHB. | |
| Layne Staley | 1967–2002 | Musician (Alice in Chains) | Cocaine, heroin and codeine overdose. | |
| Mike Starr | 1966–2011 | Musician (Alice in Chains) | Suspected drug overdose. | |
| Miroslava Stern | 1926–1955 | Actress | Overdose of sleeping pills. Suicide. | |
| Inger Stevens | 1934–1970 | Actress | Barbiturate overdose. Suicide. | |
| Bradley Stewart, aka Gidget Gein | 1969–2008 | Musician (Marilyn Manson) | Heroin overdose. | |
| Rory Storm | 1939–1972 | Musician | Alcohol and sleeping pill overdose. | |
| Margaret Sullavan | 1909–1960 | Actress | Barbiturate overdose. Suicide. | |
| James Owen Sullivan, aka The Rev | 1981–2009 | Musician (Avenged Sevenfold) | "cute polydrug intoxication due to combined effects of oxycodone, oxymorphone, diazepam, nordiazepam and ethanol." | |
| Royce Surdam | 1835–1891 | Real-estate agent | Laudanum overdose. Accidental. | |
| Jennifer Syme | 1972–2001 | Actress | Crashed her car while under the influence of cocaine, clonazepam and cyclobenzaprine. |
Read more about this topic: List Of Drug-related Deaths