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| Name | Life | Profession | Cause of death | Reference |
|---|---|---|---|---|
| Deborah Laake | 1953–2000 | Writer | Overdose of unspecified pills. Suicide. | |
| Alan Ladd | 1913–1964 | Actor | Overdose of alcohol and three unspecified drugs. Accidental. | |
| Josiah Lamborn | 1809–1847 | Attorney General | Delirium tremens. | |
| Carole Landis | 1919–1948 | Actress | Seconal overdose. Suicide. | |
| Michael Larsen aka Eyedea | 1981–2010 | Rapper | Unspecified opiate toxicity. Ruled accidental. | |
| Heath Ledger | 1979–2008 | Actor | Combined drug intoxication of oxycodone, hydrocodone, alprazolam, diazepam, temazepam and doxylamine. Accidental. | |
| Bruce Lee | 1940–1973 | Actor, martial artist | Acute cerebral edema due to a reaction to compounds present in the prescription pain killing drug Equagesic. | |
| Gerald Levert | 1966–2006 | Singer | Acute intoxication of Percocet, Vicodin, Darvocet, Xanax and two antihistamines. Accidental. | |
| Frank X. Leyendecker | 1877–1924 | Illustrator | Highly suspected morphine overdose. Suicide. | |
| Debbie Linden | 1961–1997 | Model, actress | Heroin overdose. | |
| Max Linder | 1883–1925 | Actor | Linder and his wife both drank Veronal, injected morphine and cut open the veins in their arms. | |
| Eugene Lipscomb | 1931–1963 | American football player | Heroin overdose. | |
| Eugenia Livanos | 1927–1970 | Wife of Stavros Niarchos | Barbiturate overdose. | |
| Mike Lockwood, aka Crash Holly | 1971–2003 | Professional wrestler | Carisprodol and alcohol intoxication. Suicide. | |
| Philip Loeb | 1891–1955 | Actor | Sleeping pill overdose. Suicide. | |
| Trinity Loren, aka Roxanne McPherson | 1964–1998 | Pornographic actress | Prescription painkillers overdose. In a possible suicide. | |
| Zoe Tamerlis Lund | 1962–1999 | Model, actress | Cocaine-induced heart attack. | |
| Donyale Luna | 1945–1979 | Supermodel, actress | Unspecified drug overdose. Accidental. | |
| Frankie Lymon | 1942–1968 | Singer | Heroin overdose. | |
| Phil Lynott | 1949–1986 | Musician (Thin Lizzy) | Conflicting sources report various causes of death, including: heart and liver failure, heart failure and pneumonia after a drug overdose, and blood poisoning from heroin addiction. |
Read more about this topic: List Of Drug-related Deaths