This is a list of television series in the comedy-drama genre.
- The Adventures of Brisco County, Jr. (1993-1994, Fox)
- Adventure Time (2010-, Cartoon Network)
- Against the Law (1990-1991, Fox)
- Ally McBeal (1997-2002, Fox)
- Amas de Casa Desperadas (2006-2007, El Trece)
- Amas de Casa Desperadas (2007, Teleamazonas)
- Amas de Casa Desperadas (2008, Univision)
- Angel (1999-2004, The WB)
- Auf Wiedersehen, Pet (1986-2004, ITV1/BBC One)
- Being Human (2008-, BBC Three)
- Being Human (2011-, Syfy)
- Bay City Blues (1983, NBC)
- Big Deal (1984-1986, BBC One)
- Big Shots (2007-2008, ABC)
- Blackpool (2006, BBC One)
- Bones (2005-, Fox)
- Boston Legal (2004-2008, ABC)
- The Bradys (1990, CBS)
- Buffy the Vampire Slayer (1997-2003, The WB/UPN)
- Bunheads (2012-, ABC Family)
- Burn Notice (2007-, USA)
- Candy Cabs (2011, BBC One)
- Castle (2009-, ABC)
- CHAOS (2011-, CBS)
- CHiPs (1977-1984, NBC)
- Chuck (2007-2012, NBC)
- The Commish (1991-1996, ABC)
- Common Law (2012-, USA)
- The Cosby Mysteries (1994-1995, NBC)
- Cover Me (2000-2001, USA)
- Cupid (1998-1999, ABC)
- Cupid (2009, ABC)
- Darkwing Duck (1991-1992, ABC, Syndication)
- Dead Like Me (2003-2004, Showtime)
- The Deep End (2010, ABC)
- The Defenders (2010-2011, CBS)
- Desperate Housewives (2004-2012, ABC)
- Dexter (2006-, Showtime)
- Dirk Gently (2010-2012, BBC Four)
- Dirt (2007-2008, FX)
- Dirty Sexy Money (2007-2009, ABC)
- Doc Martin (2004-, ITV1)
- Doogie Howser, M.D. (1989-1993, ABC)
- Drop Dead Diva (2009-, Lifetime)
- DuckTales (1987-1990, Broadcast syndication)
- The Dukes of Hazzard (1979-1985, CBS)
- Easy Money (2008-2009, The CW)
- Ed (2000-2004, NBC)
- Eight Is Enough (1977-1981, ABC)
- Eli Stone (2008-2009) ABC)
- Eureka (2006-2012, Syfy)
- The Finder (2012, Fox)
- Firefly (2002, Fox)
- Franklin & Bash (2011-, TNT)
- Freaks and Geeks (1999-2000, NBC)
- Fresh Meat (2011-, Channel 4)
- Futurama (1999-2003, Fox; 2008-, Comedy Central)
- Get Real (1999-2000, Fox)
- Gilmore Girls (2000-2007, The WB/The CW)
- The Glades (2010-, A&E)
- Glee (2009-, Fox)
- Glory Daze (2010-2011, TBS)
- Going to California (2001-2002, Showtime)
- The Good Guys (2010, Fox)
- Greek (2007-2011, ABC Family)
- Green Wing (2004-2007, Channel 4)
- Harry's Law (2011-2012, NBC)
- Hart of Dixie (2011-, The CW)
- Head Cases (2005, Fox)
- Hometown (1985, CBS)
- Honey, I Shrunk the Kids: The TV Show (1995-2001, Syndication)
- Huff (2004-2006, Showtime)
- I Spy (1965-1968, NBC)
- In Plain Sight (2008-2012, USA)
- The Indian Doctor (2010-, BBC One)
- Just Legal (2005-2006, The WB)
- Keen Eddie (2003, Fox)
- Kingdom (2007-2009, ITV1)
- Kingdom Hospital (2004, ABC
- The Last Precinct (1986, NBC)
- Lipstick Jungle (2008-2009, NBC)
- Lilyhammer (2012-, NRK)
- Lois & Clark: The New Adventures of Superman (1993-1997, ABC)
- Lost in Space (1965-1968, CBS)
- Love Bites (2011, NBC)
- The Love Boat (1977-1986, ABC)
- The Love Boat: The Next Wave (1998-1999, UPN)
- Love Monkey (2006, CBS)
- Men in Trees (2006-2008, ABC)
- Men of a Certain Age (2009-2011, TNT)
- The Mentalist (2008, CBS)
- Minder (1979-2009, ITV1/Channel 5)
- Miss Match (2003, NBC)
- Monk (2002-2009, USA)
- Moonlighting (1985-1989, ABC)
- My Generation (2010, ABC)
- No Ordinary Family (2010-2011, ABC)
- Northern Exposure (1990-1995, CBS)
- NY-LON (2004, Channel 4)
- Opposite Sex (2000, Fox)
- Outrageous Fortune (2005-2010, TV3)
- Personal Affairs (2009, BBC Three)
- The Powerpuff Girls (1998-2005, Cartoon Network)
- Privileged (2008-2009, The CW)
- Profit (1996, Fox)
- Psych (2006-, USA)
- Pushing Daisies (2007-2009, ABC)
- Quarterlife (2008, NBC)
- Reaper (2007-2009, The CW)
- Remington Steele (1982-1987, NBC)
- Rescue Me (2004-2011, FX)
- Rizzoli & Isles (2010, TNT)
- Scoundrels (2010, ABC)
- Scrubs (2001-2010, NBC/ABC)
- Shameless (2004-, Channel 4)
- Shameless (2011-, Showtime)
- Side Order of Life (2007, Lifetime)
- Six Feet Under (2001-2005, HBO)
- Snoops (1989-1990, CBS)
- Snoops (1999, ABC)
- St. Elsewhere (1982-1988, NBC)
- The Starter Wife (2008, USA)
- Studio 60 on the Sunset Strip (2006-2007, NBC)
- Supernatural (2005-, The WB/The CW)
- Teachers (2001-2004, Channel 4)
- Teen Wolf (2011-, MTV)
- Tequila and Bonetti (1992, CBS)
- Terriers (2011, FX)
- They Came from Outer Space (1990-1991, Syndication)
- True Blood (2008-, HBO)
- Twin Peaks (1990-1991, ABC)
- Ugly Betty (2006-2010, ABC)
- The Unusuals (2009, ABC)
- Valentine (2008-2009, The CW)
- Veronica Mars (2004-2007, UPN/The CW)
- V.I.P. (1998-2002, Syndication)
- Viva Laughlin (2007, CBS)
- Warehouse 13 (2009-, Syfy)
- The Wedding Bells (2007, Fox)
- The West Wing (1999-2006, NBC)
- The Wild Wild West (1965-1969, CBS)
- White Collar (2009-, USA)
- The Wonder Years (1988-1993, ABC)
- Wonderfalls (2004, Fox)
- Xena: Warrior Princess (1995-2001, Syndication)
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