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- Sammy Lightfoot
- Schlange CV (Homebrew)
- Schtroumpfs (European-titled 'Smurfs')
- Search for the Stolen Crown Jewels (Homebrew)
- Search for the Stolen Crown Jewels 2 (Homebrew)
- Sector Alpha
- Sewer Sam
- Side Trak (Homebrew port)
- Sir Lancelot
- Skiing
- Sky Jaguar (Homebrew port)
- Slither
- Slurpy
- Smurf Challenge (Homebrew)
- Smurf Paint 'n' Play Workshop
- Smurf: Rescue in Gargamel's Castle
- Space Fury
- Space Invaders Collection (Homebrew port)
- Space Invasion (Homebrew)
- Space Panic
- Spectar (Homebrew port)
- Spectron
- Spy Hunter
- Squares! (Homebrew)
- Squish 'Em Featuring Sam
- Star Fortress (Homebrew)
- Star Force (Homebrew)
- Star Trek: Strategic Operations Simulator
- Star Wars: The Arcade Game
- Steamroller
- Strike It
- SubRoc
- Super Action Baseball
- Super Action Football
- Super Action Soccer
- Super Cobra
- Super Crossforce
- Super Sketch
Read more about this topic: List Of ColecoVision Games