S
| Ancient name | Location | Modern name | Also known as |
| Salamis | Cyprus | abandoned | |
| Same (Σάμη) | island in the Ionian Sea, Greece | ||
| Selinus | south-west coast of Sicily, Italy | abandoned-Marinella di Selinunte | Selinunte |
| Seleucia Pieria (Σελεύκεια Πιερία) | south-eastern Turkey | Çevlik | Seleukia Pieria, Seleukia |
| Semasus | Paphlagonia, northern Turkey | Amasra | Cromna, Amastris |
| Sestos | Thracian Chersonese, Turkey | Sestus | |
| Seuthopolis | near Kazanlak, central Bulgaria | abandoned, now drowned in the Koprinka Reservoir | |
| Scidrus (Σκίδρος) | Lucania, Italy | location uncertain | |
| Sicyon (Σικυών) | northern Peloponnese, Greece | abandoned | |
| Side | Pamphylia, Turkey | abandoned | Eski Adalia, Old Antalya |
| Sidon | Lebanon | Sidon | Σιδών, Sidon, Saïda |
| Siteia | Crete, Greece | ||
| Sinope (Σινώπη) | Paphlagonia, northern Turkey | Sinop | |
| Sklavokampos | Crete, Greece | ||
| Smyrna | near Izmir, western Turkey | abandoned | Old Smyrna |
| Soli | Cyprus | abandoned | Soloi |
| Sozopolis | Pisidia, Turkey | abandoned | Apollonia |
| Sparta | southern part of the Peloponnese, Greece | Sparti | Lakedaimon (Λακεδαίμων), Lakedaimonia (Λακεδαιμωνία), Σπάρτα, Σπάρτη, Spartē. |
| Stagirus | Chalcidice, Greece | abandoned | Stageira (Στάγειρα), Stagira (Στάγιρα), Stagiros (Στάγιρος), Stageiros (Στάγειρος) |
| Stenimahos | central Bulgaria | Asenovgrad | Stenímachos (Στενήμαχος) |
| Stymphalos | Corinthia, Greece | Stymfalia | |
| Sybaris | near Sybari, Gulf of Taranto, Italy | destroyed | |
| Syracuse | east-coast of Sicily, Italy | Syracuse | Siracusai, Aretusa. |
Read more about this topic: List Of Ancient Greek Cities