Lisi may refer to:
- Lisi, a collective term for three Chadian ethnic groups
- Lisi, the city goddess at Sumerian Abu Salabikh
- LISI Interoperability Model
People with the surname Lisi:
- Antony Garrett Lisi (born 1968), American theoretical physicist
- Mark Lisi (born 1977), American soccer player
- Rick Lisi (born 1956), Canadian baseball player
- Virna Lisi (born 1937), Italian film actress
- Riccardo Galeazzi-Lisi (1891–1968), Italian medical charlatan
People with the given name Lisi:
- Lisi Harrison (born 1976), Canadian author
Places with the name Lisi:
- Lisi Lake in Tbilisi, Georgia