Regulation
LPL isozymes are regulated differently depending on the tissue. For example, insulin is known to activate LPL in adipocytes and its placement in the capillary endothelium. By contrast, insulin has been shown to decrease expression of muscle LPL.
The form that is in adipocytes is activated by insulin, whereas that in muscle and myocardium is activated by glucagon and adrenaline. This helps to explain why during fasting, LPL activity increases in muscle tissue and decreases in adipose tissue. After feasting, the opposite occurs.
The concentration of LPL displayed on endothelial cell surface cannot be regulated by endothelial cells, as they neither synthesize nor degrade LPL. Instead, this regulation occurs by managing the flux of LPL arriving at the lipolytic site and being released into circulation attached to lipoproteins. The typical concentration of LPL in plasma is in the nanomolar range.
Read more about this topic: Lipoprotein Lipase
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