Developmental Influence
lin-4 acts to dictate the onset of larval stages of developmental events in C. elegans. lin-4 loss of function (lf) mutations see a resultant retardation of developmental fates, from their initially early to instead later larval stages. Consequences include heterochronic developmental patterns, with loss of structures such as the vulva and adult cuticle. lin-4 acts as a negative regulator of lin-14 and represses accumulation of the LIN-14 protein. It also targets lin-28 and reduces its protein expression through translational inhibition. The base pairing in place between lin-4 and the target In question is discontinuous, consisting of two short helices.
Read more about this topic: Lin-4 Micro RNA Precursor
Famous quotes containing the word influence:
“The Family is the Country of the heart. There is an angel in the Family who, by the mysterious influence of grace, of sweetness, and of love, renders the fulfilment of duties less wearisome, sorrows less bitter. The only pure joys unmixed with sadness which it is given to man to taste upon earth are, thanks to this angel, the joys of the Family.”
—Giuseppe Mazzini (1805–1872)