Axial Patterning and Related Issues
Many investigations into the development of the limb skeletal pattern have been influenced by the "positional information" concept proposed by Lewis Wolpert in 1971. In tune with this idea, efforts have been made to identify diffusive signaling molecules (morphogens) that traverse orthogonal axes of developing limbs and determine locations and identities of skeletal elements in a concentration-dependent fashion.
Read more about this topic: Limb Development
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