Storylines
Lexie Grey is the daughter of Thatcher Grey and his wife, Susan. She also has a younger sister, Molly Thompson, and her older half-sister is Meredith Grey (Ellen Pompeo), born to Thatcher and his first wife, Ellis. On her first appearance she flirted with Derek. She graduated from Harvard Medical School before being accepted to Seattle Grace Hospital as an intern. The character's initial plans were to perform her internship at a different hospital, Mass General, however, these changed when her mother died from sudden complications. She is introduced as Cristina Yang (Sandra Oh)'s intern, who dubs her "three". When Meredith discovers that Lexie is her sister, she shows no desire to maintain a friendship, though the two eventually kindle a relationship. Lexie forms a friendship with fellow intern George O'Malley (T.R. Knight), and the two rent an apartment together. Furthermore, she later pursues a sexual relationship with resident Alex Karev (Justin Chambers). Lexie develops romantic feelings for O'Malley in the fifth season, however, he shows no interest in a romantic relationship, and their friendship dissolves. Lexie and fellow interns form a "medieval" medical teaching club, in the basement of the hospital, which leads to them all being placed on disciplinary probation.
Lexie develops a romantic relationship with plastic surgeon Mark Sloan (Eric Dane), despite the efforts of Meredith and her husband, Derek Shepherd (Patrick Dempsey)—they feel he will hurt her. In the sixth season, O'Malley dies, after injuries sustained while being dragged by a bus, and Lexie receives comfort from Sloan, by moving in with him. Later in the season, Thatcher is admitted into the hospital, subsequently being diagnosed with liver failure—a repercussion from his former alcoholism. It is revealed that he needs an organ transplant, and Lexie offers to donate, but she is not a viable candidate. After constant pleads from Lexie, Meredith unwillingly agrees to donate her liver to Thatcher. In "Holidaze", Sloan's daughter shows up at their apartment, seeking kinship with him. His daughter soon announces her pregnancy, and Sloan offers shelter for her and the baby. However, when Lexie finds out, she is piqued that Sloan did not discuss this with her, and the two break up. On the spur of the moment, Lexie and Karev engage in sexual activity while his wife, Izzie Stevens (Katherine Heigl) is estranged, and the two form a relationship.
During the season six finale, a grieving deceased patient's husband goes on a shooting rampage at the hospital, and shoots Karev. In the shooting's emotional reverberations, Lexie goes into a mental state, is admitted to the hospital's psychiatric facility, and gets sedated for fifty hours. Karev cannot deal with this, and ends his relationship with Lexie, leaving her enraged. Their breakup is followed by Lexie returning to Sloan, who condemned Karev for leaving her. However, Lexie later discovers that during their breakup, Sloan impregnated orthopedic surgeon Callie Torres (Sara Ramirez), and she ends their relationship, again. In the aftermath of the breakup, Lexie agrees to a date with fellow resident, Jackson Avery (Jesse Williams), and the two entertain a brief relationship. In season eight, Lexie becomes jealous of Sloan's new girlfriend, Julia, which leads to Avery breaking up with her. Thereafter, Lexie confesses her undying love to Sloan, only to be ignored. In "Flight", however, Lexie, Sloan, Meredith, Shepherd, Yang, and pediatric surgeon Arizona Robbins (Jessica Capshaw), are involved in an aviation accident, crushing Lexie under debris. It is revealed that Lexie is suffering from a hemothorax, and that she will die. Sloan takes her by the hand, and tells her he will always love her, and that they were meant to be. Lexie subsequently succumbs to her injuries, and dies as Meredith is approaching.
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