Cell Biology
A Lewy body is composed of the protein alpha-synuclein associated with other proteins, such as ubiquitin, neurofilament protein, and alpha B crystallin. Tau proteins may also be present, and Lewy bodies may occasionally be surrounded by neurofibrillary tangles (NFTs). Lewy bodies and NFTs can occasionally exist in the same neuron, particularly in the amygdala.
Lewy bodies are believed to represent an aggresome response in the cell.
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