Leukocyte Extravasation - Leukocyte Adhesion Deficiency

Leukocyte Adhesion Deficiency

Leukocyte adhesion deficiency (LAD) is a genetic disease associated with a defect in the leukocyte extravasation process, caused by a defective integrin β2 chain (found in LFA-1 and Mac-1). This impairs the ability of the leukocytes to stop and undergo diapedesis. People with LAD suffer from recurrent bacterial infections and impaired wound healing. Neutrophilia is a hallmark of LAD.

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Famous quotes containing the word deficiency:

    “It is easier to discover a deficiency in individuals, in states, and in Providence, than to see their real import and value.”
    —Georg Wilhelm Friedrich Hegel (1770–1831)