Lethal White Syndrome - Analogous Conditions

Analogous Conditions

From very early in research into its genetics, lethal white syndrome has been compared to Hirschsprung's disease (HSCHR) in humans, which is also caused by mutations on the EDNRB gene. Various polymorphisms on this gene result in intestinal agangliosis, in some cases attended by unusual pigmentation of the skin and eyes, and deafness. The occasionally attendant pigmentation condition in humans is called Waardenburg-Shah syndrome.

The terms "piebald-lethal" and "spotting lethal" apply to similar conditions in mice and rats respectively, both caused by mutations on the EDNRB gene. Only lethal in the homozygous state, the mutations are associated with white-spotted coats, deafness, and megacolon caused by intestinal agangliosis.

Read more about this topic:  Lethal White Syndrome

Famous quotes containing the words analogous and/or conditions:

    If thinking is like perceiving, it must be either a process in which the soul is acted upon by what is capable of being thought, or a process different from but analogous to that. The thinking part of the soul must therefore be, while impassable, capable of receiving the form of an object; that is, must be potentially identical in character with its object without being the object. Mind must be related to what is thinkable, as sense is to what is sensible.
    Aristotle (384–322 B.C.)

    Ours is a culture based on excess, on overproduction; the result is a steady loss of sharpness in our sensory experience. All the conditions of modern life—its material plenitude, its sheer crowdedness—conjoin to dull our sensory faculties.
    Susan Sontag (b. 1933)