Least squares inference in phylogeny generates a phylogenetic tree based on an observed matrix of pairwise genetic distances and optionally a weight matrix. The goal is to find a tree which satisfies the distance constraints as best as possible.
Read more about Least Squares Inference In Phylogeny: Ordinary and Weighted Least Squares, Generalized Least Squares, Computational Complexity
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—Ezra Pound (1885–1972)
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—Ralph Waldo Emerson (1803–1882)