Principles
LDL apheresis works by leading venous blood through a column coated with antibodies to apolipoprotein B (the main protein of LDL particles), dextran sulfate or polyacrylate, or by precipitating LDL with heparin at low pH. In all cases (apart from polyacrylate absorption), plasma is separated from cells by a cell separator.
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—David Hume (1711–1776)