La Romana may refer to:
- La Romana Province, in the Dominican Republic
- La Romana, Dominican Republic, capital city of the province
- La Romana, Alicante, a municipality in Alicante, Spain
- Pedro Caro y Sureda, 3rd marqués de La Romana (1761–1811), Spanish general
- The Woman of Rome (Italian: La Romana), a novel by Alberto Moravia