La Reina del Sur may refer to:
- La Reina del Sur, a Spanish novel by Arturo Pérez-Reverte
- The Queen of the South (novel), a translation by Andrew Hurley of the novel into English
- Queen of the South (film), a film adaptation of the novel
- La Reina del Sur (telenovela), an adaptation of the novel for television
- La Reina del Sur 2, a sequel to the first television adaptation
- La Reina del Sur (album), an album by Los Tigres del Norte
- "La Reina del Sur", a song written by Teodoro Bello Jaimes. It was recorded by Los Tigres del Norte for the album of the same name. It was then covered by Los Cuates de Sinaloa for the theme music to the first telenovela.