La Luna can refer to
- The Moon
- La Luna (1979 film), a 1979 film by Italian director Bernardo Bertolucci
- La Luna (2011 film), a 2012 short film from Pixar
- La Luna (album), a 2000 album by English soprano Sarah Brightman
- La Luna: Live in Concert, a 2001 Sarah Brightman concert inspired by that album
- "La Luna" (song), a 1989 song by Belinda Carlisle
- La Luna (Holger Czukay album), a 2000 album by Holger Czukay
- "La Luna", a piece of music composed by Ottmar Liebert
- La Luna (Portland, Oregon), a defunct Portland, Oregon nightclub