Dyosa tells the story of Josephine who grew up unaware of her true identity as the " Takda" (Chosen One) and how she learns of her lineage and destiny in the world of gods and goddesses. The Takda who hails from the Kabanua is chosen to save humankind from the imbalance brought about by the evil forces of Kasamyans. Josephine lives in the world of mortals where she meets a comic illustrator, Mars (Zanjoe Marudo) from Makiling Publishing who draws the fate of the Dyosa with the powers from sky, earth, and water - Cielo, Tierra, Agua. Unknown to Mars, Josephine is the same as Dyosa whom he has fallen for in the form of Dyosa Cielo. Cielo is torn between her love for the mortal life - the mortal, Mars - and her duty as Takda.
Josephine is a young orphan who finally finds out she is no ordinary mortal after reaching the age of 18. After years of being raised by her foster parents, Josephine finds out she is the 'Takda' or Chosen One with divine powers and must help save the world from the Kasamyan, who are evil creatures from Lower Earth. After becoming a full-fledged goddess, Josephine also discovers that she has the power of the earth, air and water. To harness these powers, she takes the form of Dyosa Tierra, a centauride, Dyosa Agua, a mermaid, and Dyosa Cielo, a harpy. However, Josephine has to choose whether to heed the call of her destiny, to save the dying world of the gods and goddesses and to leave the life she has lived for 18 year or to resist her new role as a goddess and to give up her powers to stay in the human world with the mortal she loves.
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