Kretschmer is a surname and may refer to:
- Ernst Kretschmer (1888–1964), German psychiatrist
- Marian Kretschmer (born 1983), German comics artist
- Otto Kretschmer (1912–1998), German U-Boat commander in World War II
- Paul Kretschmer (1866–1956), German linguist
- Daniel Kretschmer, German hip hop and reggae musician
- Tim Kretschmer (1991–2009), German spree killer
- Jaroslava Kretschmer (* 1955), Czech actress
- Václav Kretschmer (1849–1921), Czech painter
- Otto Kretschmer (1790–1811), Czech manufacturer of musical instruments
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