KPO may refer to:
- KPO (radio station), a San Francisco radio station now broadcasting under the call sign KNBR
- Communist Party of Austria (German: Kommunistische Partei Österreichs, KPÖ)
- Communist Party of Germany (Opposition) (German: Kommunistische Partei Deutschlands (Opposition))
- Knowledge process outsourcing
- Ku-ring-gai Philharmonic Orchestra, of Australia
- Pohang Airport Pohang, South Korea
- Karachaganak Petroleum Operating, operator of the Karachaganak Field