Koff may refer to:
- Koff, a Finnish beer brewed by Sinebrychoff
- Clea Koff (forensic anthropologist) (born 1972)
- Richard M. Koff, Writer (Christopher and His Magic Powers)
- Offutt Air Force Base (ICAO code KOFF)
- Koff (ship type), a historical type of sailing vessel in the North Sea