Related Ideas
Field cancerisation may be an extended form of the Knudson hypothesis. This is the phenomenon of various primary tumours developing in one particular area of the body, suggesting that an earlier "hit" predisposed the whole area for cancer.
Announced in 2011, chromothripsis similarly involves multiple mutations, but asserts that they may all appear at once. This idea, affecting only 2–3% of cases of cancer, although up to 25% of bone cancers, involves the catastrophic shattering of a chromosome into tens or hundreds of pieces and then being patched back together incorrectly. This shattering, it is presumed, takes place when the chromosomes are compacted during normal cell division, but the trigger for the shattering is unknown. Under this model, cancer arises as the result of a single, isolated event, rather than the slow accumulation of multiple mutations.
Read more about this topic: Knudson Hypothesis
Famous quotes containing the words related and/or ideas:
“Becoming responsible adults is no longer a matter of whether children hang up their pajamas or put dirty towels in the hamper, but whether they care about themselves and others—and whether they see everyday chores as related to how we treat this planet.”
—Eda Le Shan (20th century)
“Chinese were born ... with an accumulated wisdom, a natural sophistication, an intelligent naivete, and unless they were transplanted too young, these qualities ripened in them.... If ever I am homesick for China, now that I am home in my own country, it is when I discover here no philosophy. Our people have opinions and creeds and prejudices and ideas but as yet no philosophy.”
—Pearl S. Buck (1892–1973)