Knob may refer to:

  • A rounded handle that one pulls or twists:
    • Doorknob, a round handle one turns to open any door
    • Control knob, controls a device
    • Brodie knob on the steering wheel
  • A prominent rounded hill or mountain, particularly in the Appalachians and the Ozarks
  • Another word for tow ball or hitch ball
  • Protrusions on the surface of erythrocytes associated with Maurer's clefts in malaria
  • In slang, the male genitalia.