Research Directions
Crystallization of calcium oxalate appears to be inhibited by certain substances in the urine that retard the formation, growth, aggregation, and adherence of crystals to renal cells. By purifying urine using salt precipitation, isoelectric focusing, and size-exclusion chromatography, some researchers have found that calgranulin, a protein formed in the kidney, is a potent inhibitor of the in vivo formation of calcium oxalate crystals. Considering its extremely high levels of inhibition of growth and aggregation of calcium oxalate crystals, calgranulin might be an important intrinsic factor in the prevention of nephrolithiasis.
Read more about this topic: Kidney Stone
Famous quotes containing the words research and/or directions:
“Our science has become terrible, our research dangerous, our findings deadly. We physicists have to make peace with reality. Reality is not as strong as we are. We will ruin reality.”
—Friedrich Dürrenmatt (19211990)
“Have we any control over being born?, my friend asked in despair. No, the job is done for us while were sleeping, so to speak, and when we wake up everything is all set. We merely appear, like an ornate celebrity wheeled out in a wheelchair. I dont remember, my friend claimed. No need to, I said: what need have us free-loaders for any special alertness? Were done for.”
—Marvin Cohen, U.S. author and humorist. The Self-Devoted Friend, New Directions (1967)