Uses in The Heart and Brain
Ketone bodies can be used for energy. Ketone bodies are transported from the liver to other tissues, where acetoacetate and beta-hydroxybutyrate can be reconverted to acetyl-CoA to produce energy, via the citric acid cycle.
The heart preferentially utilizes fatty acids for energy under normal physiologic conditions. However, under ketotic conditions, the heart can effectively utilize ketone bodies for energy.
The brain gets a portion of its energy from ketone bodies when glucose is less available (e.g., during fasting, strenuous exercise, low carbohydrate, ketogenic diet and in neonates). In the event of low blood glucose, most other tissues have additional energy sources besides ketone bodies (such as fatty acids), but the brain does not. After the diet has been changed to lower blood glucose for 3 days, the brain gets 25% of its energy from ketone bodies. After about 4 days, this goes up to 70% (during the initial stages the brain does not burn ketones, since they are an important substrate for lipid synthesis in the brain).
Read more about this topic: Ketone Bodies
Famous quotes containing the words heart and/or brain:
“Give sorrow words; the grief that does not speak
Whispers the o’er-fraught heart and bids it break.”
—William Shakespeare (1564–1616)
“To me the sole hope of human salvation lies in teaching Man to regard himself as an experiment in the realization of God, to regard his hands as God’s hand, his brain as God’s brain, his purpose as God’s purpose. He must regard God as a helpless Longing, which longed him into existence by its desperate need for an executive organ.”
—George Bernard Shaw (1856–1950)