Kazimierz Sapieha can refer to:
- Jan Kazimierz Sapieha the Younger, (ca. 1637/1642–1720), since 1700 held the title of a Duke. Since 1681 Field Hetman of Lithuania, voivod of Vilnius since 1682, and Grand Hetman of Lithuania since 1682 .
- Jan Kazimierz Sapieha the Elder (17th century–1730), Grand Hetman of Lithuania
- Kazimierz Nestor Sapieha
- Kazimierz Władysław Sapieha
- Tomasz Kazimierz Sapieha
- Aleksander Kazimierz Sapieha
- Antoni Kazimierz Sapieha
- Kazimierz Mikołaj Sapieha
- Kazimierz Melchiades Sapieha