John Lyons may refer to:
- John Lyons (American football) (born 1952), American football coach
- John Lyons (bishop) (1878–1958), Bishop of Ontario, 1932–1952
- John Lyons (UK politician) (born 1949), Labour Party politician
- John Lyons (Antiguan politician) (1760–1816), Antiguan politician
- John Lyons (VC) (1824–1867), Irish soldier in the British army, recipient of the Victoria Cross
- John Lyons (ice hockey) (1900–1971), United States ice hockey player who competed in the 1924 Winter Olympics
- John Lyons (horse trainer), author and horse trainer in the field of natural horsemanship
- John Lyons (hurler) (born 1924), Irish sportsperson
- John Lyons (linguist) (born 1932), British linguist
- John Lyons (actor) (born 1943), British actor
- John Lyons (footballer) (1956–1982), Welsh footballer
- John J. Lyons (c. 1881–1945), Secretary of State of New York, 1921–1922
- John Lyons (Longford politician), Irish independent / Labour Party politician, represented Longford-Westmeath, 1922–1927
- John Lyons (Dublin politician) (born 1977), Irish Labour politician representing Dublin North West since 2011
- J. B. Lyons (1922–2007), John Binignus Lyons, Irish medical historian and writer
- John P. Lyons (1876–?), Canadian diver
- John W. Lyons, mayor of Cambridge, Massachusetts