Jesenice is a toponym that can refer to either of the two meanings of the Slavic word "jesen": "ash tree" and "autumn".
Jesenice may refer to:
- Jesenice, Jesenice, a town in the Municipality of Jesenice in northwest Slovenia
- Jesenice, Brežice, a village in the Municipality of Brežice in southeast Slovenia, near the border with Croatia
- Jesenice (Prague-West District) or Jesenice u Prahy, a town in the Czech Republic
- Jesenice (Rakovník District), a village in the Czech Republic
- Jesenice (Příbram District), a village in the Czech Republic
- Jesenice, Croatia, a settlement near Dugi Rat, consisting of the villages of Krilo, Orij, and Suhi Potok