Evolution
The virus appears to have originated from its ancestral virus in the mid 1500s in the Indonesia-Malaysia region and evolved there into five different genotypes and spread across Asia. The mean evolutionary rate has been estimated to be 4.35×10(-4) (range: 3.4906×10(-4) to 5.303×10(-4)) nucleotide substitutions per site per year.
Read more about this topic: Japanese Encephalitis
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