The Janus Kinase Family
The four JAK family members are:
- Janus kinase 1 (JAK1)
- Janus kinase 2 (JAK2)
- Janus kinase 3 (JAK3)
- Tyrosine kinase 2 (TYK2)
Transgenic mice that do not express JAK1 have defective responses to some cytokines, such as interferon-gamma. JAK1 and JAK2 are involved in type II interferon (interferon-gamma) signalling, whereas JAK1 and TYK2 are involved in type I interferon signalling. Mice that do not express TYK2 have defective natural killer cell function.
Read more about this topic: Janus Kinase
Famous quotes containing the word family:
“Having a thirteen-year-old in the family is like having a general-admission ticket to the movies, radio and TV. You get to understand that the glittering new arts of our civilization are directed to the teen-agers, and by their suffrage they stand or fall.”
—Max Lerner (b. 1902)